The world is mourning the loss of Prince Frederik of Luxembourg, who bravely fought POLG mitochondrial disease, a rare and devastating genetic disorder. He passed away on March 1, 2025, in Paris, as confirmed by his family on the POLG Foundation website.
What is POLG Mitochondrial Disease?
POLG mitochondrial disease is a rare genetic condition that affects the body's ability to produce energy at the cellular level, leading to progressive organ failure.
Key Facts About POLG:
No cure or effective treatment currently exists for this disease.
Affects millions worldwide—Over 300 million people suffer from rare diseases, many of which remain undiagnosed or are identified too late.
Prince Frederik was diagnosed with POLG at the age of 14. Despite his struggles, he remained resilient and dedicated his life to raising awareness and supporting research for a cure.
A Legacy of Courage and Advocacy
In 2022, Prince Frederik established the POLG Foundation to fund research and find potential treatments. His father, Prince Robert of Luxembourg, shared a heartfelt message about his son’s dedication:
"Frederik and the POLG Foundation are dedicated to discovering treatments and a cure to prevent others from experiencing the hardships that Frederik and our family have faced."
Prince Frederik’s Key Contributions:
Raising awareness—He worked tirelessly to educate the public about POLG and other rare diseases.
Participating in clinical trials—Frederik volunteered in medical studies to aid researchers in their quest for treatments.
Inspiring hope—Despite his condition, he remained optimistic and focused on making a difference in others' lives.
A Heartfelt Goodbye
Prince Frederik passed away just one day after Rare Disease Day, a poignant reminder of the struggles faced by those living with rare conditions. His father shared a moving account of his final moments:
"He gathered the strength and courage to say goodbye to each of us—his brother, sister, cousins, and loved ones—one by one."
Even in his last days, Frederik remained disciplined. His Italian Duolingo and exercise alarms went off as usual, reflecting his unwavering determination.
A Message of Gratitude and Hope
Prince Frederik often expressed gratitude for his life despite the hardships. A close friend revealed one of his most touching statements:
"Frederik once said, ‘I’m glad that I was the one born with this disease. Even though I’ll die from it, I know my parents will save other children.’"
His selflessness and commitment to helping others will be remembered forever.
Honoring Prince Frederik’s Legacy
Prince Frederik’s work through the POLG Foundation continues to inspire and bring hope to families affected by rare diseases. His father summed up his enduring impact beautifully:
"One light was extinguished, but so many remain."
Let us honor Prince Frederik’s memory by supporting rare disease research and advocacy.
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